South Brisbane is strategically positioned along the southern bank of the Brisbane River, with its northern, eastern, and northwestern boundaries defined by the river’s median. The suburb is bordered by Woolloongabba to the east, Highgate Hill to the south, and West End to the southwest. The stretch of the river adjacent to South Brisbane is known as the South Brisbane Reach.

The suburb enjoys seamless connectivity to Brisbane’s central business district via six key bridges. These include the Go Between Bridge (a toll road), William Jolly Bridge (for road traffic), Merivale Bridge (for rail services), Kurilpa Bridge (for pedestrians and cyclists), Victoria Bridge (for road traffic), and Goodwill Bridge (for pedestrians and cyclists).

South Brisbane’s transport infrastructure extends beyond bridges, with train stations at South Brisbane and South Bank, along with South East Busway stations at Cultural Centre, South Bank, and Mater Hill. Additionally, the CityCat ferry service provides convenient access to various riverside suburbs, further enhancing connectivity.

With its prime location, robust transport options, and proximity to key business and cultural hubs, South Brisbane remains a vital part of Brisbane’s urban landscape.