South Brisbane has experienced significant demographic shifts over the past decade, reflecting its evolution into a dynamic and diverse urban hub.

According to the 2011 census, the suburb had a population of 5,416, with a near-equal gender distribution—48.8% female and 51.2% male. The median age was 30, seven years younger than the Australian median, and a notable 33.3% of residents were in their twenties, highlighting South Brisbane’s appeal to younger demographics.

The area has long been a multicultural centre, with 44.2% of residents in 2011 born in Australia—lower than the national average of 69.8%. Other common countries of birth included England (3.8%), New Zealand (3.7%), China (3.3%), South Korea (3%), and India (2%). English was the primary language for 57.2% of residents, while Mandarin (5.5%), Korean (2.8%), Cantonese (2.7%), Greek (2.1%), and Arabic (1.9%) were also widely spoken. Religious affiliations were equally diverse, with 30% identifying as having no religion, followed by Catholic (19%), Anglican (8.5%), Buddhism (4.6%), and Islam (3.8%).

By the 2016 census, the suburb's population had surged to 7,196, demonstrating steady growth driven by increased urban development and the suburb’s attractiveness to professionals, students, and migrants.

The most dramatic population increase came in the 2021 census, where South Brisbane’s population doubled to 14,292. This rapid expansion is largely attributed to high-density residential developments, improved infrastructure, and its proximity to the city centre, making it one of Brisbane’s most sought-after areas.

Beyond its demographic evolution, South Brisbane is also home to many heritage-listed buildings, reflecting its historical significance. As one of Brisbane’s oldest suburbs, it boasts a rich architectural and cultural heritage, with notable sites preserved to maintain the area’s historic charm while accommodating modern growth.

With its diverse community, vibrant lifestyle, and deep-rooted history, South Brisbane continues to be a key player in Brisbane’s ongoing urban transformation.