South Brisbane has a rich history of religious and civic development, marked by both progress and challenges. By the late 19th century, the growing Catholic community found St Mary’s Catholic Church too small for its congregation. Between 1884 and 1889, additional land was acquired, allowing for the construction of a new St Mary's Church in 1890. Designed by architects George Simkin and John Ibler, the church incorporated Italianate and Romanesque Revival elements and could accommodate 800 worshippers. The foundation stone was laid by Cardinal Patrick Francis Moran on 25 September 1892, and the church was officially opened on 2 July 1893 by Archbishop Robert Dunne. Although plans for a tower and transepts were never realized, a sanctuary addition was completed in 1929. The Sisters of Mercy later opened St Mary’s School in 1909, which remained in operation until its closure in 1964.

Another notable church, the Catholic Apostolic Church, was first established in Queensland in June 1888 at Manning Street. Designed by architect Leslie Corrie, the structure was intended to be expanded over time. However, a fire destroyed the church on 21 July 1917. A new brick church, designed by George Addison, was built later that year. After its minister Joseph Todd Young passed away in 1932, the church continued under its deacons until 1957. The Anglican Church eventually purchased the building in 1962.

South Brisbane was significantly impacted by the devastating Brisbane River flood of February 1893. Approximately 350 hectares (860 acres) were submerged, with water levels reaching up to 4.8 meters (16 feet). Only the roofs of some buildings remained visible. The flood left Stanley Street, then the area's main thoroughfare, in ruins. The South Brisbane Congregational Church in Grey Street suffered severe damage, prompting the congregation to relocate to a higher site on Vulture Street. Using salvaged materials from the old church, a new building was constructed and opened on 23 July 1893. Unfortunately, the church was later destroyed in a fire on 16 October 1931. The congregation continued worshiping in the hall until a new church was completed in 1933.

Amidst these challenges, South Brisbane continued its urban development. On 16 June 1897, the city's first electric tramway was introduced along Stanley Street, marking a major advancement in public transportation. These historical milestones reflect South Brisbane’s resilience and continuous evolution through the years.